1. Danzo: Danzo is one of the top leaders of Konoha Village and the superior of Uchiha Itachi. Danzo threatens Itachi to carry out his mission, which leads to tragedy.
2. Uchiha Obito: Obito is the leader behind the Akatsuki organization, and Itachi knows his true identity. Itachi accepted Danzo's order to stop the war and was full of hatred for Obito.
3. Orochimaru: Orochimaru is Itachi's first partner in the Akatsuki organization, but he is not Itachi's opponent. Orochimaru has ambitions for Itachi's younger brother Sasuke and asks Itachi to pay attention to his whereabouts.
4. Kabuto Yakushi: Kabuto Yakushi is Orochimaru's careerist and helped Obito launch the Fourth Ninja War. Without his help, Obito might not be able to defeat the ninja coalition.
5. Deidara: Deidara was defeated by Itachi when he joined the Akatsuki organization, and he held a grudge against Itachi and Sasuke. He almost killed Sasuke and was annoying to Itachi to the core.