1. Orochimaru: A disciple of the third generation Hokage Sarutobi Hiruzen, he left Konoha Village and joined the Akatsuki organization, and finally left and founded Otogakure Village.
2. Itachi Uchiha: The genius ninja of Konoha Village. After becoming a rebel, he massacred the Uchiha clan. He was eventually reincarnated by Kabuto Yakushi and helped Sasuke and his soul ascended to heaven.
3. Obito Uchiha: Originally regarded as a hero, he was later controlled by Madara Uchiha to attack Konoha with the Nine-Tails. Finally, he turned to protect Naruto and died at the hands of Kaguya.
4. Uchiha Madara: A ninja from Konoha Village who left Konoha for peace and faith. He was finally defeated and resurrected in the Valley of the End. He finally knew the truth but his life came to an end.
5. Uchiha Sasuke: He rebelled against the village in pursuit of power, planned to destroy Konoha, and his revenge triggered the Great Ninja War, and finally became the Hokage of Konoha Village.
6. Mizuki: A follower of Orochimaru, he lured Naruto to steal the Sealed Book. He was eventually beaten by a group of multiple shadow clones and died from an overdose of medicine.