1. Orochimaru: A disciple of the third generation Hokage Sarutobi Hiruzen, he left Konoha Village and joined the Akatsuki organization, and finally left and founded Otogakure Village.
2. Itachi Uchiha: The genius ninja of Konoha Village. After becoming a rebel, he massacred the Uchiha clan. He was eventually reincarnated by Kabuto Yakushi and helped Sasuke and his soul ascended to heaven.
3. Obito Uchiha: Originally regarded as a hero, he was later controlled by Madara Uchiha to attack Konoha with the Nine-Tails. Finally, he turned to protect Naruto and died at the hands of Kaguya.
4. Uchiha Madara: A ninja from Konoha Village who left Konoha for peace and faith.
5. Uchiha Sasuke: He rebelled against the village in pursuit of power, planned to destroy Konoha, and his revenge triggered the Great Ninja War, and finally became the Hokage of Konoha Village.
6. Mizuki: A follower of Orochimaru, he lured Naruto to steal the Sealed Book. He was eventually beaten by a group of multiple shadow clones and died from an overdose of medicine.