1. Second Hokage Tobirama Senju: Tobirama Senju, known for his speed and forbidden jutsu, tragically died at the hands of the Kinkaku and Ginkaku squads. Although weaker, they had the advantage of surprise and enhanced abilities from the Nine-Tailed Fox chakra. Tobirama sacrificed himself to protect his disciples.

2. Fourth Hokage Minato Namikaze: Minato Namikaze, the Yellow Flash, died in the Nine-Tails attack, despite his skills and the Flying Thunder God technique. He sacrificed himself to protect Konoha and his loved ones.

3. First Hokage Hashirama Senju: Considered the most powerful shinobi, Hashirama died under mysterious circumstances after defeating Madara Uchiha.

Despite his strong constitution, he died early for the sake of plot development.

4. Third Kazekage: Killed by Sasori, the strongest Kazekage's body was turned into a human puppet. The Sand Village fell into a war triggered by his death.

5. Fourth Kazekage: Rasa, possessing the crucial Magnet Release, was assassinated by Orochimaru during the Konoha Crush operation. Sunagakure discovered his death after the operation failed. These tragic deaths showcased the strength of these leaders and added depth to the plot. They also emphasized the harsh realities of the Shinobi world.